Chitosan and its modification for gene delivery / 中国组织工程研究

Gene vectors are of great importance in gene therapy.Research on non-viral gene vectors has become the most urgent issue as viral gene vectors have shown a series of safety problems during clinical application.Chitosan is one of the best potential non-viral gene vectors because of its excellent physico-chemical and biological properties.In recent years,a lot of works have been done on chitosan and its modification for gene delivery,and valuable progresses have been achieved.In this paper,recent progresses in chitosan and its modified derivates for gene delivery are reviewed in temls of size,stability,specific targeting ability and gene transfection efficiency of the chitosan/gene complex.